This paper studies $n$-person simultaneous-move games with linear best response function, where individuals interact within a given network structure. This class of games have been used to model various settings, such as, public goods, belief formation, peer effects, and oligopoly. The purpose of this paper is to study the effect of the network structure on Nash equilibrium outcomes of this class of games. Bramoullé et al. derived conditions for uniqueness and stability of a Nash equilibrium in terms of the smallest eigenvalue of the adjacency matrix representing the network of interactions. Motivated by this result, we study how local structural properties of the network of interactions affect this eigenvalue, influencing game equilibria. In particular, we use algebraic graph theory and convex optimization to derive new bounds on the smallest eigenvalue in terms of the distribution of degrees, cycles, and other relevant substructures. We illustrate our results with numerical simulations involving online social networks.