Modern networked systems are constantly under threat from systemic attacks. There has been a massive upsurge in the number of devices connected to a network as well as the associated traffic volume. This has intensified the need to better understand all possible attack vectors during system design and implementation. Further, it has increased the need to mine large data sets, analyzing which has become a daunting task. It is critical to scale monitoring infrastructures to match this need, but a difficult goal for the small and medium organization. Hence, there is a need to propose novel approaches that address the big data problem in security. Information Centrality (IC) labels network nodes with better vantage points for detecting network-based anomalies as central nodes and uses them for detecting a category of attacks called systemic attacks. The main idea is that since these central nodes already see a lot of information flowing through the network, they are in a good position to detect anomalies before other nodes. This research first dives into the importance of using graphs in understanding the topology and information flow. We then introduce the usage of information centrality, a centrality-based index, to reduce data collection in existing communication networks. Using IC-identified central nodes can accelerate outlier detection when armed with a suitable anomaly detection technique. We also come up with a more efficient way to compute Information centrality for large networks. Finally, we demonstrate that central nodes detect anomalous behavior much faster than other non-central nodes, given the anomalous behavior is systemic in nature.