As LLM-based multi-agent systems (MAS) become more autonomous, their free-form interactions increasingly dominate system behavior. However, scaling the number of agents often amplifies context pressure, coordination errors, and system drift. It is well known that building robust MAS requires more than prompt tuning or increased model intelligence. It necessitates engineering discipline focused on architecture to manage complexity under uncertainty. We characterize agentic software by a core property: \emph{runtime generation and evolution under uncertainty}. Drawing upon and extending software engineering experience, especially object-oriented programming, this paper introduces \emph{Loosely-Structured Software (LSS)}, a new class of software systems that shifts the engineering focus from constructing deterministic logic to managing the runtime entropy generated by View-constructed programming, semantic-driven self-organization, and endogenous evolution. To make this entropy governable, we introduce design principles under a three-layer engineering framework: \emph{View/Context Engineering} to manage the execution environment and maintain task-relevant Views, \emph{Structure Engineering} to organize dynamic binding over artifacts and agents, and \emph{Evolution Engineering} to govern the lifecycle of self-rewriting artifacts. Building on this framework, we develop LSS design patterns as semantic control blocks that stabilize fluid, inference-mediated interactions while preserving agent adaptability. Together, these abstractions improve the \emph{designability}, \emph{scalability}, and \emph{evolvability} of agentic infrastructure. We provide basic experimental validation of key mechanisms, demonstrating the effectiveness of LSS.