In this paper, we present the Python package PSY-TaLiRo which is a toolbox for temporal logic robustness guided falsification of Cyber-Physical Systems (CPS). PSY-TaLiRo is a completely modular toolbox supporting multiple temporal logic offline monitors as well as optimization engines for test case generation. Among the benefits of PSY-TaLiRo is that it supports search-based test generation for many different types of systems under test. All PSY-TaLiRo modules can be fully modified by the users to support new optimization and robustness computation engines as well as any System under Test (SUT).