Modeling and Simulation (M&S) is finding increasing application in development and testing of command and control systems comprised of information-intensive component systems. Achieving interoperability is one of the chief System of Systems (SoS) engineering objectives in the development of command and control (C2) capabilities for joint and coalition warfare. In this paper, we apply an SoS perspective on the integration of M&S with such systems. We employ recently developed interoperability concepts based on linguistic categories along with the Discrete Event System Specification (DEVS) formalism to implement a standard for interoperability. We will show how the developed standard is implemented in DEVS/SOA net-centric modeling and simulation framework that uses XML-based Service Oriented Architecture (SOA). We will discuss the simulator interfaces and the design issues in their implementation in DEVS/SOA. We will illustrate the application of DEVS/SOA in a multi-agent test instrumentation system that is deployable as a SOA.