Business process enactment is generally supported by information systems that record data about process executions, which can be extracted as event logs. Predictive process monitoring is concerned with exploiting such event logs to predict how running (uncompleted) cases will unfold up to their completion. In this paper, we propose a predictive process monitoring framework for estimating the probability that a given predicate will be fulfilled upon completion of a running case. The predicate can be, for example, a temporal logic constraint or a time constraint, or any predicate that can be evaluated over a completed trace. The framework takes into account both the sequence of events observed in the current trace, as well as data attributes associated to these events. The prediction problem is approached in two phases. First, prefixes of previous traces are clustered according to control flow information. Secondly, a classifier is built for each cluster using event data to discriminate between fulfillments and violations. At runtime, a prediction is made on a running case by mapping it to a cluster and applying the corresponding classifier. The framework has been implemented in the ProM toolset and validated on a log pertaining to the treatment of cancer patients in a large hospital.