Model-based engineering promises to boost productivity and quality of complex systems development. In the context of safety-critical systems, a traditionally highly regulated and conservative domain, the use of models gained importance in the recent years. In this paper, we present a set of practical challenges in developing safety-critical systems with the help of several examples of development projects that belong to different application domains. Following this, we show how could the adoption of model-based engineering for the development of safety-critical systems cope with these challenges.