Failures in safety-critical Cyber-Physical Systems (CPS), both software and hardware-related, can lead to severe incidents impacting physical infrastructure or even harming humans. As a result, extensive simulations and field tests need to be conducted, as part of the verification and validation of system requirements, to ensure system safety. However, current simulation and field testing practices, particularly in the domain of small Unmanned Aerial Systems (sUAS), are ad-hoc and lack a thorough, structured testing process. Furthermore, there is a dearth of standard processes and methodologies to inform the design of comprehensive simulation and field tests. This gap in the testing process leads to the deployment of sUAS applications that are: (a) tested in simulation environments which do not adequately capture the real-world complexity, such as environmental factors, due to a lack of tool support; (b) not subjected to a comprehensive range of scenarios during simulation testing to validate the system requirements, due to the absence of a process defining the relationship between requirements and simulation tests; and (c) not analyzed through standard safety analysis processes, because of missing traceability between simulation testing artifacts and safety analysis artifacts. To address these issues, we have developed an initial framework for validating CPS, specifically focusing on sUAS and robotic applications. We demonstrate the suitability of our framework by applying it to an example from the sUAS domain. Our preliminary results confirm the applicability of our framework. We conclude with a research roadmap to outline our next research goals along with our current proposal.