Anomalies in complex industrial processes are often obscured by high variability and complexity of event data, which hinders their identification and interpretation using process mining. To address this problem, we introduce WISE (Weighted Insights for Evaluating Efficiency), a novel method for analyzing business process metrics through the integration of domain knowledge, process mining, and machine learning. The methodology involves defining business goals and establishing Process Norms with weighted constraints at the activity level, incorporating input from domain experts and process analysts. Individual process instances are scored based on these constraints, and the scores are normalized to identify features impacting process goals. Evaluation using the BPIC 2019 dataset and real industrial contexts demonstrates that WISE enhances automation in business process analysis and effectively detects deviations from desired process flows. While LLMs support the analysis, the inclusion of domain experts ensures the accuracy and relevance of the findings.