With the current trend in Model-Based Systems Engineering towards Digital Engineering and early Validation & Verification, experiments are increasingly used to estimate system parameters and explore design decisions. Managing such experimental configuration metadata and results is of utmost importance in accelerating overall design effort. In particular, we observe it is important to 'intelligent-ly' reuse experiment-related data to save time and effort by not performing potentially superfluous, time-consuming, and resource-intensive experiments. In this work, we present a framework for managing experiments on digital and/or physical assets with a focus on case-based reasoning with domain knowledge to reuse experimental data efficiently by deciding whether an already-performed experiment (or associated answer) can be reused to answer a new (potentially different) question from the engineer/user without having to set up and perform a new experiment. We provide the general architecture for such an experiment manager and validate our approach using an industrial vehicular energy system-design case study.