Critical-infrastructure operators are increasingly expected to assess and remediate vulnerabilities in deployed industrial software. However, much of this software exists as opaque industrial software (OIS), including stripped firmware, proprietary protocol handlers, and compiled control logic without source code, symbols, build environments, or hardware interfaces. While binary analysis can identify vulnerability candidates, existing automated repair systems largely rely on source code, compilable artifacts, sanitizer feedback, or instrumentable builds, leaving a gap between binary-level discovery and validated remediation. This paper presents SCARA, a Semantics-Constrained Autonomous Remediation Agent for OIS. SCARA operates under a source-unavailable defender model and connects upstream binary vulnerability candidates to conditionally validated remedies through a four-stage pipeline. Operational-state-aware verification (OSVA) filters infeasible candidates using a nine-component industrial state model; remediation synthesis (RSA) selects the strongest available remedy across protocol mitigation, binary hardening, and SSCKG-constrained source patches; and correctness validation (CVA) provides conditional correctness evidence via behavioral-coverage preservation, independent replay, and typed rejection feedback. On OIS-RemedBench, a 15-case benchmark spanning firmware, protocol handlers, and ICS/PLC artifacts, SCARA achieves observed 100% precision with no false positives, refutes 20.0% of cases as operationally infeasible, and reaches 88.9% remediation success after targeted reruns. To our knowledge, SCARA is the first end-to-end framework that connects binary vulnerability candidates to conditionally validated remediation for opaque industrial software.