The emergence of quantum computing proposes a revolutionary paradigm that can radically transform numerous scientific and industrial application domains. The ability of quantum computers to scale computations exponentially imply better performance and efficiency for certain algorithmic tasks than current computers provide. However, to gain benefit from such improvement, quantum computers must be integrated with existing software systems, a process that is not straightforward. In this paper, we investigate challenges that emerge from building larger hybrid classical-quantum computers, and discuss some approaches that could be employed to overcome these challenges.