Combinatorial interaction testing (CIT) is a well-known technique, but the industrial experience is needed to determine its effectiveness in different application domains. We present a case study introducing a unified framework for generating, executing and verifying CIT test suites, based on the open-source Avocado test framework. In addition, we present a new industrial case study to demonstrate the effectiveness of the framework. This evaluation showed that the new framework can generate, execute, and verify effective combinatorial interaction test suites for detecting configuration failures (invalid configurations) in a virtualization system.