Deep Neural Networks (DNN) will emerge as a cornerstone in automotive software engineering. However, developing systems with DNNs introduces novel challenges for safety assessments. This paper reviews the state-of-the-art in verification and validation of safety-critical systems that rely on machine learning. Furthermore, we report from a workshop series on DNNs for perception with automotive experts in Sweden, confirming that ISO 26262 largely contravenes the nature of DNNs. We recommend aerospace-to-automotive knowledge transfer and systems-based safety approaches, e.g., safety cage architectures and simulated system test cases.