Search-based Software Testing (SBST) can automatically generate test cases to search for requirements violations. Unlike manual test case development, it can generate a substantial number of test cases in a limited time. However, SBST does not possess the domain knowledge of engineers. Several techniques have been proposed to integrate engineers' domain knowledge within existing SBST frameworks. This paper will reflect on recent experimental results by highlighting bold and unexpected results. It will help re-examine SBST techniques driven by domain knowledge from a new perspective, suggesting new directions for future research.