The recent events affecting global society continuously highlight the need to change the development lifecycle of complex systems by promoting human-centered solutions that increase awareness and ensure critical properties such as security, safety, trust, transparency, and privacy. This fast abstract introduces the Holistic Human-Centered Development Lifecycle (2HCDL) methodology focused on: (i) the enforcement of human values and properties and (ii) the mitigation and prevention of critical issues for more secure, safe, trustworthy, transparent, and private development processes.