Software production research is quickly evolving on two parallel approaches: conventional and bio-inspired. The bio-inspired approaches are generally developed and presented as enhancements of the conventional ones. However the conventional approaches benefit from their integration with their global context, through software engineering methodologies, for being advantageous.The integration of bio-inspired approaches with bio-inspired software engineering methodologies will enrich them and let them be irrefutably be the best. This paper identify the motivations to the emergence of such bio-inspired software engineering, presents a first approach to it, with a road map, and some of its challenges.The application of this first approach on different software systems categories is presented with its summary evaluation. However, the evaluation on industrial scale remains a challenge.