The Deep Noise Suppression (DNS) challenge is designed to foster innovation in the area of noise suppression to achieve superior perceptual speech quality. This is the 4th DNS challenge, with the previous editions held at INTERSPEECH 2020, ICASSP 2021, and INTERSPEECH 2021. We open-source datasets and test sets for researchers to train their deep noise suppression models, as well as a subjective evaluation framework based on ITU-T P.835 to rate and rank-order the challenge entries. We provide access to DNSMOS P.835 and word accuracy (WAcc) APIs to challenge participants to help with iterative model improvements. In this challenge, we introduced the following changes: (i) Included mobile device scenarios in the blind test set; (ii) Included a personalized noise suppression track with baseline; (iii) Added WAcc as an objective metric; (iv) Included DNSMOS P.835; (v) Made the training datasets and test sets fullband (48 kHz). We use an average of WAcc and subjective scores P.835 SIG, BAK, and OVRL to get the final score for ranking the DNS models. We believe that as a research community, we still have a long way to go in achieving excellent speech quality in challenging noisy real-world scenarios.