We present DESAMO, an on-device smart home system for elder-friendly use powered by Audio LLM, that supports natural and private interactions. While conventional voice assistants rely on ASR-based pipelines or ASR-LLM cascades, often struggling with the unclear speech common among elderly users and unable to handle non-speech audio, DESAMO leverages an Audio LLM to process raw audio input directly, enabling a robust understanding of user intent and critical events, such as falls or calls for help.