Speech enhancement at extremely low signal-to-noise ratio (SNR) condition is a very challenging problem and rarely investigated in previous works. This paper proposes a robust speech enhancement approach (UNetGAN) based on U-Net and generative adversarial learning to deal with this problem. This approach consists of a generator network and a discriminator network, which operate directly in the time domain. The generator network adopts a U-Net like structure and employs dilated convolution in the bottleneck of it. We evaluate the performance of the UNetGAN at low SNR conditions (up to -20dB) on the public benchmark. The result demonstrates that it significantly improves the speech quality and substantially outperforms the representative deep learning models, including SEGAN, cGAN fo SE, Bidirectional LSTM using phase-sensitive spectrum approximation cost function (PSA-BLSTM) and Wave-U-Net regarding Short-Time Objective Intelligibility (STOI) and Perceptual evaluation of speech quality (PESQ).