The audio-visual sound separation field assumes visible sources in videos, but this excludes invisible sounds beyond the camera's view. Current methods struggle with such sounds lacking visible cues. This paper introduces a novel "Audio-Visual Scene-Aware Separation" (AVSA-Sep) framework. It includes a semantic parser for visible and invisible sounds and a separator for scene-informed separation. AVSA-Sep successfully separates both sound types, with joint training and cross-modal alignment enhancing effectiveness.