Spatial audio is essential for immersive experiences, yet novel-view acoustic synthesis (NVAS) remains challenging due to complex physical phenomena such as reflection, diffraction, and material absorption. Existing methods based on single-view or panoramic inputs improve spatial fidelity but fail to capture global geometry and semantic cues such as object layout and material properties. To address this, we propose Phys-NVAS, the first physics-aware NVAS framework that integrates spatial geometry modeling with vision-language semantic priors. A global 3D acoustic environment is reconstructed from multi-view images and depth maps to estimate room size and shape, enhancing spatial awareness of sound propagation. Meanwhile, a vision-language model extracts physics-aware priors of objects, layouts, and materials, capturing absorption and reflection beyond geometry. An acoustic feature fusion adapter unifies these cues into a physics-aware representation for binaural generation. Experiments on RWAVS demonstrate that Phys-NVAS yields binaural audio with improved realism and physical consistency.