We propose an end-to-end speaker verification system based on the neural network and trained by a loss function with less computational complexity. The end-to-end speaker verification system in this paper consists of a ResNet architecture to extract features from utterance, then produces utterance-level speaker embeddings, and train using the large-margin Gaussian Mixture loss function. Influenced by the large-margin and likelihood regularization, large-margin Gaussian Mixture loss function benefits the speaker verification performance. Experimental results demonstrate that the Residual CNN with large-margin Gaussian Mixture loss outperforms DNN-based i-vector baseline by more than 10% improvement in accuracy rate.