The IEEE Spoken Language Technology Workshop (SLT) 2021 Alpha-mini Speech Challenge (ASC) is intended to improve research on keyword spotting (KWS) and sound source location (SSL) on humanoid robots. Many publications report significant improvements in deep learning based KWS and SSL on open source datasets in recent years. For deep learning model training, it is necessary to expand the data coverage to improve the robustness of model. Thus, simulating multi-channel noisy and reverberant data from single-channel speech, noise, echo and room impulsive response (RIR) is widely adopted. However, this approach may generate mismatch between simulated data and recorded data in real application scenarios, especially echo data. In this challenge, we open source a sizable speech, keyword, echo and noise corpus for promoting data-driven methods, particularly deep-learning approaches on KWS and SSL. We also choose Alpha-mini, a humanoid robot produced by UBTECH equipped with a built-in four-microphone array on its head, to record development and evaluation sets under the actual Alpha-mini robot application scenario, including noise as well as echo and mechanical noise generated by the robot itself for model evaluation. Furthermore, we illustrate the rules, evaluation methods and baselines for researchers to quickly assess their achievements and optimize their models.