Currently, high-quality, synchronized audio is synthesized using various multi-modal joint learning frameworks, leveraging video and optional text inputs. In the video-to-audio benchmarks, video-to-audio quality, semantic alignment, and audio-visual synchronization are effectively achieved. However, in real-world scenarios, speech and audio often coexist in videos simultaneously, and the end-to-end generation of synchronous speech and audio given video and text conditions are not well studied. Therefore, we propose an end-to-end multi-modal generation framework that simultaneously produces speech and audio based on video and text conditions. Furthermore, the advantages of video-to-audio (V2A) models for generating speech from videos remain unclear. The proposed framework, DeepAudio, consists of a video-to-audio (V2A) module, a text-to-speech (TTS) module, and a dynamic mixture of modality fusion (MoF) module. In the evaluation, the proposed end-to-end framework achieves state-of-the-art performance on the video-audio benchmark, video-speech benchmark, and text-speech benchmark. In detail, our framework achieves comparable results in the comparison with state-of-the-art models for the video-audio and text-speech benchmarks, and surpassing state-of-the-art models in the video-speech benchmark, with WER 16.57% to 3.15% (+80.99%), SPK-SIM 78.30% to 89.38% (+14.15%), EMO-SIM 66.24% to 75.56% (+14.07%), MCD 8.59 to 7.98 (+7.10%), MCD SL 11.05 to 9.40 (+14.93%) across a variety of dubbing settings.