B* is a novel optimization framework that addresses a critical challenge in fixed-base manipulator robotics: optimal base placement. Current methods rely on pre-computed kinematics databases generated through sampling to search for solutions. However, they face an inherent trade-off between solution optimality and computational efficiency when determining sampling resolution. To address these limitations, B* unifies multiple objectives without database dependence. The framework employs a two-layer hierarchical approach. The outer layer systematically manages terminal constraints through progressive tightening, particularly for base mobility, enabling feasible initialization and broad solution exploration. The inner layer addresses non-convexities in each outer-layer subproblem through sequential local linearization, converting the original problem into tractable sequential linear programming (SLP). Testing across multiple robot platforms demonstrates B*'s effectiveness. The framework achieves solution optimality five orders of magnitude better than sampling-based approaches while maintaining perfect success rates and reduced computational overhead. Operating directly in configuration space, B* enables simultaneous path planning with customizable optimization criteria. B* serves as a crucial initialization tool that bridges the gap between theoretical motion planning and practical deployment, where feasible trajectory existence is fundamental.