The nominal performance of mechanical systems is often degraded by unknown disturbances. A two-degree-of-freedom control structure can decouple nominal performance from disturbance rejection. However, perfect disturbance rejection is unattainable when the disturbance dynamic is unknown. In this work, we reveal an inherent trade-off in disturbance estimation subject to tracking speed and tracking uncertainty. Then, we propose two novel methods to enhance disturbance estimation: an interacting multiple model extended Kalman filter-based disturbance observer and a multi-kernel correntropy extended Kalman filter-based disturbance observer. Experiments on an exoskeleton verify that the proposed two methods improve the tracking accuracy $36.3\%$ and $16.2\%$ in hip joint error, and $46.3\%$ and $24.4\%$ in knee joint error, respectively, compared to the extended Kalman filter-based disturbance observer, in a time-varying interaction force scenario, demonstrating the superiority of the proposed method.