Current invasive assistive technologies are designed to infer high-dimensional motor control signals from severely paralyzed patients. However, they face significant challenges, including public acceptance, limited longevity, and barriers to commercialization. Meanwhile, noninvasive alternatives often rely on artifact-prone signals, require lengthy user training, and struggle to deliver robust high-dimensional control for dexterous tasks. To address these issues, this study introduces a novel human-centered multimodal AI approach as intelligent compensatory mechanisms for lost motor functions that could potentially enable patients with severe paralysis to control high-dimensional assistive devices, such as dexterous robotic arms, using limited and noninvasive inputs. In contrast to the current state-of-the-art (SoTA) noninvasive approaches, our context-aware, multimodal shared-autonomy framework integrates deep reinforcement learning algorithms to blend limited low-dimensional user input with real-time environmental perception, enabling adaptive, dynamic, and intelligent interpretation of human intent for complex dexterous manipulation tasks, such as pick-and-place. The results from our ARAS (Adaptive Reinforcement learning for Amplification of limited inputs in Shared autonomy) trained with synthetic users over 50,000 computer simulation episodes demonstrated the first successful implementation of the proposed closed-loop human-in-the-loop paradigm, outperforming the SoTA shared autonomy algorithms. Following a zero-shot sim-to-real transfer, ARAS was evaluated on 23 human subjects, demonstrating high accuracy in dynamic intent detection and smooth, stable 3D trajectory control for dexterous pick-and-place tasks. ARAS user study achieved a high task success rate of 92.88%, with short completion times comparable to those of SoTA invasive assistive technologies.