Abstract:This study proposes a transferable encoding strategy that maps tactile sensor data to electrical stimulation patterns, enabling neural organoids to perform an open-loop artificial tactile Braille classification task. Human forebrain organoids cultured on a low-density microelectrode array (MEA) are systematically stimulated to characterize the relationship between electrical stimulation parameters (number of pulse, phase amplitude, phase duration, and trigger delay) and organoid responses, measured as spike activity and spatial displacement of the center of activity. Implemented on event-based tactile inputs recorded from the Evetac sensor, our system achieved an average Braille letter classification accuracy of 61% with a single organoid, which increased significantly to 83% when responses from a three-organoid ensemble were combined. Additionally, the multi-organoid configuration demonstrated enhanced robustness against various types of artificially introduced noise. This research demonstrates the potential of organoids as low-power, adaptive bio-hybrid computational elements and provides a foundational encoding framework for future scalable bio-hybrid computing architectures.
From: Tianyi Liu [view email]
[v1]
Thu, 28 Aug 2025 14:44:25 UTC (3,219 KB)
[v2]
Fri, 6 Feb 2026 12:34:03 UTC (3,724 KB)
[v3]
Mon, 7 Sep 2026 14:22:53 UTC (3,847 KB)
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