This paper proposes MOON (Multi-Objective Optimization-driven Object-goal Navigation), a novel framework designed for efficient navigation in large-scale, complex indoor environments. While existing methods often rely on local heuristics, they frequently fail to address the strategic trade-offs between competing objectives in vast areas. To overcome this, we formulate the task as a multi-objective optimization problem (MOO) that balances frontier-based exploration with the exploitation of observed landmarks. Our prototype integrates three key pillars: (1) QOM [IROS05] for discriminative landmark encoding; (2) StructNav [RSS23] to enhance the navigation pipeline; and (3) a variable-horizon Set Orienteering Problem (SOP) formulation for globally coherent planning. To further support the framework's scalability, we provide a detailed theoretical foundation for the budget-constrained SOP formulation and the data-driven mode-switching strategy that enables long-horizon resource allocation. Additionally, we introduce a high-speed neural planner that distills the expert solver into a transformer-based model, reducing decision latency by a factor of nearly 10 while maintaining high planning quality.