Vision-based robot learning often relies on dense image or point-cloud inputs, which are computationally heavy and entangle irrelevant background features. Existing keypoint-based approaches can focus on manipulation-centric features and be lightweight, but either depend on manual heuristics or task-coupled selection, limiting scalability and semantic understanding. To address this, we propose AFFORD2ACT, an affordance-guided framework that distills a minimal set of semantic 2D keypoints from a text prompt and a single image. AFFORD2ACT follows a three-stage pipeline: affordance filtering, category-level keypoint construction, and transformer-based policy learning with embedded gating to reason about the most relevant keypoints, yielding a compact 38-dimensional state policy that can be trained in 15 minutes, which performs well in real-time without proprioception or dense representations. Across diverse real-world manipulation tasks, AFFORD2ACT consistently improves data efficiency, achieving an 82% success rate on unseen objects, novel categories, backgrounds, and distractors.