One of the challenges of Industry 4.0, is to determine and optimize the flow of data, products and materials in manufacturing companies. To realize these challenges, many solutions have been defined such as the utilization of automated guided vehicles (AGVs). However, being guided is a handicap for these vehicles to fully meet the requirements of Industry 4.0 in terms of adaptability and flexibility: the autonomy of vehicles cannot be reduced to predetermined trajectories. Therefore, it is necessary to develop their autonomy. This will be possible by designing new generations of industrial autonomous vehicles (IAVs), in the form of intelligent and cooperative autonomous mobile robots.In the field of road transport, research is very active to make the car autonomous. Many algorithms, solving problematic traffic situations similar to those that can occur in an industrial environment, can be transposed in the industrial field and therefore for IAVs. The technologies standardized in dedicated bodies (e.g., ETSI TC ITS), such as those concerning the exchange of messages between vehicles to increase their awareness or their ability to cooperate, can also be transposed to the industrial context. The deployment of intelligent autonomous vehicle fleets raises several challenges: acceptability by employees, vehicle location, traffic fluidity, vehicle perception of changing environments (dynamic), vehicle-infrastructure cooperation, or vehicles heterogeneity. In this context, developing the autonomy of IAVs requires a relevant working method. The identification of reusable or adaptable algorithms to the various problems raised by the increase in the autonomy of IAVs is not sufficient, it is also necessary to be able to model, to simulate, to test and to experiment with the proposed solutions. Simulation is essential since it allows both to adapt and to validate the algorithms, but also to design and to prepare the experiments.To improve the autonomy of a fleet, we consider the approach relying on a collective intelligence to make the behaviours of vehicles adaptive. In this chapter, we will focus on a class of problems faced by IAVs related to collision and obstacle avoidance. Among these problems, we are particularly interested when two vehicles need to cross an intersection at the same time, known as a deadlock situation. But also, when obstacles are present in the aisles and need to be avoided by the vehicles safely.