Powered ankle-foot prostheses can often reduce the energy cost of walking by assisting with push-off. However, focus on providing mechanical work may lead to ignoring or exacerbating common issues with chronic pain, irritation, pressure ulcer development, and eventual osteoarthritis in persons with amputation. This paper presents the design and validation of a novel transtibial prosthesis informed by predictive biomechanical simulations of gait which minimize a combination of user effort and interaction loading from the prosthesis socket. From these findings, the device was designed with a non-biomimetic anterior-posterior translation degree of freedom with a 10 cm range of motion which is primarily position-controlled to change the alignment of the prosthetic foot with the residual limb. The system is both mobile and tethered, with the batteries, actuators, and majority of electronics located in a small backpack. Mechanical loads are transmitted through cables to the prosthesis, minimizing the distal mass carriage required. We measured torque and force sensing accuracy, open loop actuator performance, closed loop torque and position control bandwidth, and torque and position tracking error during walking. The system is capable of producing up to 160 N-m of plantarflexion torque and 394 N of AP translation force with a closed loop control bandwidth of about 7 Hz in both degrees of freedom. Torque tracking during walking was accurate within about 10 N-m but position tracking was substantially affected by phase lag, possibly due to cable slack in the bidirectional mechanism. The prototype was capable of replicating our simulated prosthesis dynamics during gait and offers useful insights into the advantages and the practical considerations of using predictive biomechanical simulation as a design tool for wearable robots.