The performance of industrial robotic work cells depends on optimizing various hyperparameters referring to the cell layout, such as robot base placement, tool placement, and kinematic design. Achieving this requires a bilevel optimization approach, where the high-level optimization adjusts these hyperparameters, and the low-level optimization computes robot motions. However, computing the optimal robot motion is computationally infeasible, introducing trade-offs in motion planning to make the problem tractable. These trade-offs significantly impact the overall performance of the bilevel optimization, but their effects still need to be systematically evaluated. In this paper, we introduce metrics to assess these trade-offs regarding optimality, time gain, robustness, and consistency. Through extensive simulation studies, we investigate how simplifications in motion-level optimization affect the high-level optimization outcomes, balancing computational complexity with solution quality. The proposed algorithms are applied to find the time-optimal kinematic design for a modular robot in two palletization scenarios.