Evolutionary algorithms (EAs) are very popular tools to design and evolve artificial neural networks (ANNs), especially to train them. These methods have advantages over the conventional backpropagation (BP) method because of their low computational requirement when searching in a large solution space. In this paper, we employ Chemical Reaction Optimization (CRO), a newly developed global optimization method, to replace BP in training neural networks. CRO is a population-based metaheuristics mimicking the transition of molecules and their interactions in a chemical reaction. Simulation results show that CRO outperforms many EA strategies commonly used to train neural networks.