The complexity of performance-based building design stems from the evaluation of numerous candidate design options, driven by the plethora of variables, objectives, and constraints inherent in multi-disciplinary projects. This necessitates optimization approaches to support the identification of well performing designs while reducing the computational time of performance evaluation. In response, this paper proposes and evaluates a sequential approach for multi-objective design optimization of building geometry, fabric, HVAC system and controls for building performance. This approach involves sequential optimizations with optimal solutions from previous stages passed to the next. The performance of the sequential approach is benchmarked against a full factorial search, assessing its effectiveness in finding global optima, solution quality, reliability to scale and variations of problem formulations, and computational efficiency compared to the NSGA-II algorithm. 24 configurations of the sequential approach are tested on a multi-scale case study, simulating 874 to 4,147,200 design options for an office building, aiming to minimize energy demand while maintaining thermal comfort. A two-stage sequential process-(building geometry + fabric) and (HVAC system + controls) identified the same Pareto-optimal solutions as the full factorial search across all four scales and variations of problem formulations, demonstrating 100% effectiveness and reliability. This approach required 100,700 function evaluations, representing a 91.2% reduction in computational effort compared to the full factorial search. In contrast, NSGA-II achieved only 73.5% of the global optima with the same number of function evaluations. This research indicates that a sequential optimization approach is a highly efficient and robust alternative to the standard NSGA-II algorithm.