Estimation of Distribution Algorithms (EDAs) require flexible probability models that can be efficiently learned and sampled. Restricted Boltzmann Machines (RBMs) are generative neural networks with these desired properties. We integrate an RBM into an EDA and evaluate the performance of this system in solving combinatorial optimization problems with a single objective. We assess how the number of fitness evaluations and the CPU time scale with problem size and with problem complexity. The results are compared to the Bayesian Optimization Algorithm, a state-of-the-art EDA. Although RBM-EDA requires larger population sizes and a larger number of fitness evaluations, it outperforms BOA in terms of CPU times, in particular if the problem is large or complex. RBM-EDA requires less time for model building than BOA. These results highlight the potential of using generative neural networks for combinatorial optimization.