In this paper we focus on problems which do not admit a constant-factor approximation in polynomial time and explore how quickly their approximability improves as the allowed running time is gradually increased from polynomial to (sub-)exponential. We tackle a number of problems: For Min Independent Dominating Set, Max Induced Path, Forest and Tree, for any $r(n)$, a simple, known scheme gives an approximation ratio of $r$ in time roughly $r^{n/r}$. We show that, for most values of $r$, if this running time could be significantly improved the ETH would fail. For Max Minimal Vertex Cover we give a non-trivial $\sqrt{r}$-approximation in time $2^{n/r}$. We match this with a similarly tight result. We also give a $\log r$-approximation for Min ATSP in time $2^{n/r}$ and an $r$-approximation for Max Grundy Coloring in time $r^{n/r}$. Furthermore, we show that Min Set Cover exhibits a curious behavior in this super-polynomial setting: for any $δ> 0$ it admits an $m^δ$-approximation, where $m$ is the number of sets, in just quasi-polynomial time. We observe that if such ratios could be achieved in polynomial time, the ETH or the Projection Games Conjecture would fail.