A maximal matching can be maintained in fully dynamic (supporting both addition and deletion of edges) $n$-vertex graphs using a trivial deterministic algorithm with a worst-case update time of O(n). No deterministic algorithm that outperforms the naïve O(n) one was reported up to this date. The only progress in this direction is due to Ivković and Lloyd \cite{IL93}, who in 1993 devised a deterministic algorithm with an \emph{amortized} update time of $O((n+m)^{\sqrt{2}/2})$, where $m$ is the number of edges. In this paper we show the first deterministic fully dynamic algorithm that outperforms the trivial one. Specifically, we provide a deterministic \emph{worst-case} update time of $O(\sqrt{m})$. Moreover, our algorithm maintains a matching which is in fact a 3/2-approximate maximum cardinality matching (MCM). We remark that no fully dynamic algorithm for maintaining $(2-\eps)$-approximate MCM improving upon the naïve O(n) was known prior to this work, even allowing amortized time bounds and \emph{randomization}. For low arboricity graphs (e.g., planar graphs and graphs excluding fixed minors), we devise another simple deterministic algorithm with \emph{sub-logarithmic update time}. Specifically, it maintains a fully dynamic maximal matching with amortized update time of $O(\log n/\log \log n)$. This result addresses an open question of Onak and Rubinfeld \cite{OR10}. We also show a deterministic algorithm with optimal space usage, that for arbitrary graphs maintains a maximal matching in amortized $O(\sqrt{m})$ time, and uses only $O(n+m)$ space.