Deploying deep neural network (DNN) accelerators with Layer Temporal Scheduling (LTS) often incurs significant overheads (e.g., energy and latency), as intermediate activations must be cached in DRAM. To alleviate this, Tile Spatial Scheduling (TSS) reduces such costs by fragmenting inter-layer data into smaller tiles communicated via on-chip links.However, many emerging applications require concurrent execution of multiple DNNs with complex topologies, where critical tasks must preempt others to meet stringent latency requirements (e.g., in autonomous driving, obstacle detection must complete within tens of milliseconds). Existing TSS works lack support for preemption, while prior preemption schemes rely on LTS and thus inherit its overheads. This highlights the need for preemptive and efficient TSS-based frameworks. Yet, realizing such systems is challenging due to the complexity of enabling preemption in graphs with large-scale topologies (e.g., modern large language models may contain tens of thousands of edges). To tackle this, we present IsoSched, the first framework enabling preemptive multi-DNN scheduling on TSS architecture. IsoSched first formulates scheduling of complex-topology graphs as an integer-linear program (ILP) and subgraph isomorphism problem; second, it applies Layer Concatenate and Split (LCS) for load balancing in tile pipelines; third, it employs an Ullmann-based algorithm enhanced by Monte Carlo Tree Search (MCTS) to accelerate subgraph matching, and uses compact matrix encoding (i.e., Compressed Sparse Row, CSR) to reduce memory usage. IsoSched outperforms LTS-PRM approaches (i.e., PREMA, Planaria, CD-MSA, MoCA) in Latency-Bound Throughput (LBT), speedup, and energy efficiency, and achieves higher critical task satisfaction than TSS-NPRM (i.e., HASP) across varying task complexities.