Computational Science on large high performance computing resources is hampered by the complexity of these systems. Much of this complexity is due to low-level details on these resources that are exposed to the application and the end user. This includes (but is not limited to) mechanisms for remote access, configuring and building applications from source code, and managing simulations and their output files via batch queue systems. These challenges multiply in a modern research environment, where a research collaboration spans multiple groups, often in loosely defined international collaborations, where there is a constant influx of new students into multi-year projects, and where simulations are performed on several different resources. The Simulation Factory addresses these challenges by significantly simplifying remote access, building executables, and managing simulations. By abstracting out the low-level differences between different resources, it offers a uniform interface to these resources. At the same time, it can enforce certain standards for performing simulations that encapsulate best practices from experienced users. Furthermore, SimFactory's automation avoids many possible user errors that can in the worst case render month-long simulations worthless.