Recent advancements in satellite technologies and the declining cost of access to space have led to the emergence of large satellite constellations in Low Earth Orbit. However, these constellations often rely on bent-pipe architecture, resulting in high communication costs. Existing onboard inference architectures suffer from limitations in terms of low accuracy and inflexibility in the deployment and management of in-orbit applications. To address these challenges, we propose a cloud-native-based satellite design specifically tailored for Earth Observation tasks, enabling diverse computing paradigms. In this work, we present a case study of a satellite-ground collaborative inference system deployed in the Tiansuan constellation, demonstrating a remarkable 50\% accuracy improvement and a substantial 90\% data reduction. Our work sheds light on in-orbit energy, where in-orbit computing accounts for 17\% of the total onboard energy consumption. Our approach represents a significant advancement of cloud-native satellite, aiming to enhance the accuracy of in-orbit computing while simultaneously reducing communication cost.