The requirement of supporting both latency sensitive and computing intensive Internet of Things (IoT) applications is consistently boosting the necessity for integrating Edge, Fog and Cloud infrastructure. Although there are a number of real-world frameworks attempt to support such integration, they have many limitations from various perspectives including platform independence, security, resource management and multi-application assistance. To address these limitations, we propose a simplified but effective framework, named FogBus for facilitating end-to-end IoT-Fog(Edge)-Cloud integration. FogBus offers a platform independent interface to IoT applications and computing instances for execution and interaction. It not only assists developers in building applications but also helps users in running multiple applications at a time and service providers to manage their resources. In addition, FogBus applies Blockchain, authentication and encryption techniques to secure operations on sensitive data. Because of its lightweight and cross platform software systems, it is easy to deploy, scalable and cost e_cient. We demonstrate the effectiveness of our framework by creating a computing environment with it that integrates finger pulse oximeter as IoT devices with Smartphone-based gateway and Raspberry Pi-based Fog nodes for Sleep Apnea analysis. We also run several experiments on this computing environment varying FogBus settings. The experimental results show that different FogBus settings can improve latency, energy, network and CPU usage of the computing infrastructure.