This volume contains the proceedings of PROHA 2016, the first workshop on Program Transformation for Programmability in Heterogeneous Architectures, held on March 12, 2016 in Barcelona, Spain, as an affiliated workshop of CGO 2016, the 14th International Symposium on Code Generation and Optimization. Developing and maintaining high-performance applications and libraries for heterogeneous architectures while preserving its semantics and with a reasonable efficiency is a time-consuming task which is often only possible for experts. It often requires manually adapting sequential, platform-agnostic code to different infrastructures, and keeping the changes in all of these infrastructures in sync. These program modification tasks are costly and error-prone. Tools to assist in and, if possible, automate such transformations are of course of great interest. However, such tools may need significant reasoning and knowledge processing capabilities, including, for example, being able to process machine-understandable descriptions of the semantics of a piece of code is expected to do; to perform program transformations inside a context in which they are applicable; to use strategies to identify the sequence of transformations leading to the best resulting code; and others.