The Compact Muon Solenoid (CMS) experiment at the Large Hadron Collider (LHC) is one of the largest data producers in the scientific world, with standard data products centrally produced, and then used by often competing teams within the collaboration. This work is focused on how a local institution, University of California San Diego (UCSD), partnered with the Open Science Grid (OSG) to use Azure cloud resources to augment its available computing to accelerate time to results for multiple analyses pursued by a small group of collaborators. The OSG is a federated infrastructure allowing many independent resource providers to serve many independent user communities in a transparent manner. Historically the resources would come from various research institutions, spanning small universities to large HPC centers, based on either community needs or grant allocations, so adding commercial clouds as resource providers is a natural evolution. The OSG technology allows for easy integration of cloud resources, but the data-intensive nature of CMS compute jobs required the deployment of additional data caching infrastructure to ensure high efficiency.