Increasingly deeper integration of HPC resources and QPUs unveils new challenges in computer architecture and engineering. As a consequence, dependability arises again as a concern encompassing resilience, reproducibility and security. The properties of quantum computing systems involve a reinterpretation of these factors in retrodictive, predictive, and prescriptive ways. We state here that resilience must become an \emph{a priori} design constraint rather than an afterthought of HPC-QPU integration. This article describes the need for conceptual and quantitative models to estimate and assess the resilience hybrid classical-quantum computing infrastructure. We suggest how resilience methods in civil engineering can apply at various levels of the classical-quantum computing stack. We also discuss implications of a model of end-user value for the estimation of consequences resulting from the propagation of vulnerabilities from a given level of the stack upwards. Finally, we argue in favor of new resilience models can help the impact of improving specific components in quantum technology stacks to provide a clearer picture about the value of separation of concerns across different layers. Ultimately, HPC-QPU integration will increasingly demand more precise statements about the cost-benefit ratio of specific system improvements and their cascading consequences against estimates of delivered value to users.