HPC environments have traditionally been designed to meet the compute demand of scientific applications and data has only been a second order concern. With science moving toward data-driven discoveries relying more on correlations in data to form scientific hypotheses, the limitations of HPC approaches become apparent: Architectural paradigms such as the separation of storage and compute are not optimal for I/O intensive workloads (e.g. for data preparation, transformation and SQL). While there are many powerful computational and analytical libraries available on HPC (e.g. for scalable linear algebra), they generally lack the usability and variety of analytical libraries found in other environments (e.g. the Apache Hadoop ecosystem). Further, there is a lack of abstractions that unify access to increasingly heterogeneous infrastructure (HPC, Hadoop, clouds) and allow reasoning about performance trade-offs in this complex environment. At the same time, the Hadoop ecosystem is evolving rapidly and has established itself as de-facto standard for data-intensive workloads in industry and is increasingly used to tackle scientific problems. In this paper, we explore paths to interoperability between Hadoop and HPC, examine the differences and challenges, such as the different architectural paradigms and abstractions, and investigate ways to address them. We propose the extension of the Pilot-Abstraction to Hadoop to serve as interoperability layer for allocating and managing resources across different infrastructures. Further, in-memory capabilities have been deployed to enhance the performance of large-scale data analytics (e.g. iterative algorithms) for which the ability to re-use data across iterations is critical. As memory naturally fits in with the Pilot concept of retaining resources for a set of tasks, we propose the extension of the Pilot-Abstraction to in-memory resources.