We study the problem of computing shortest path or distance between two query vertices in a graph, which has numerous important applications. Quite a number of indexes have been proposed to answer such distance queries. However, all of these indexes can only process graphs of size barely up to 1 million vertices, which is rather small in view of many of the fast-growing real-world graphs today such as social networks and Web graphs. We propose an efficient index, which is a novel labeling scheme based on the independent set of a graph. We show that our method can handle graphs of size three orders of magnitude larger than those existing indexes.