Graph databases have grown in popularity in recent years as they are able to efficiently store and query complex relationships between data. Incidentally, navigation data and road networks can be processed, sampled or modified efficiently when stored as a graph. As a result, graph databases are a solution for solving route planning tasks that comes more and more to the attention of developers of autonomous vehicles. To achieve a computational performance that enables the realization of route planning on large road networks or for a great number of agents concurrently, several aspects need to be considered in the design of the solution. Based on a concrete use case for centralized route planning, we discuss the characteristics and properties of a use case that can significantly influence the computational effort or efficiency of the database management system. Subsequently we evaluate the performance of both Neo4j and ArangoDB depending on these properties. With these results, it is not only possible to choose the most suitable database system but also to improve the resulting performance by addressing relevant aspects in the design of the application.