Join queries involving many relations pose a severe challenge to today's query optimisation techniques. To some extent, this is due to the fact that these techniques do not pay sufficient attention to structural properties of the query. In stark contrast, the Database Theory community has intensively studied structural properties of queries (such as acyclicity and various notions of width) and proposed efficient query evaluation techniques through variants of Yannakakis' algorithm. However, although most queries in practice actually are acyclic or have low width, structure-guided query evaluation techniques based on Yannakakis' algorithm have not found their way into mainstream database technology yet. The goal of this work is to address this gap between theory and practice and to demonstrate that the consideration of query structure can improve query evaluation performance on modern DBMSs significantly in cases that have been traditionally challenging. In particular, we study the performance of structure-guided query evaluation in three architecturally distinct DBMSs by rewriting SQL queries into a sequence of SQL statements that express an execution of Yannakakis' algorithm. Moreover, we identify a class of queries that is particularly well suited for our approach and allows query answering in a variety of common scenarios without materializing any join. Through empirical evaluation we show that structure-guided query evaluation can make the evaluation of many difficult join queries feasible whereas their evaluation requires a prohibitive amount of time and memory on current DBMSs.